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Opioid action is because of both equally lower affinity binding on the guardian compound and higher affinity binding with the O-demethylated metabolite M1 to μ-opioid receptors. In animal models, M1 is as many as 6 times extra powerful than tramadol in manufacturing analgesia and 200 occasions extra powerful in μ-opioid https://gear4d.com/product/tramadol-hcl-50mg/

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