G allele (A118G) are very poor responders to morphine, and have to have bigger doses from the drug To alleviate suffering. In addition, morphine and its metabolites really have to cross the BBB and penetrate the CNS to conduct their action: it was demonstrated that suffering relief variability, in https://fernandogatka.blog-a-story.com/7607035/the-proleviate-natures-morphine-diaries