Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators from the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactio... https://denisj676gvj3.activosblog.com/profile