This refers to how an allosteric modulator impacts signaling for a specific orthosteric agonist. For example, an allosteric modulator may well change THC signaling, although not endogenous cannabinoid signaling. An important opportunity endogenous negative allosteric modulator for CB1 is the steroid hormone, pregnenolone [40–forty two]. Some (although not all [forty https://carcrashcompensation05667.ezblogz.com/64444850/a-review-of-endocannabinoid-system