There is a launch of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to reduce afferent pain transmission and deliver analgesia. Thus, medicines like clonidine that target alpha-two receptors can affect the transmission of discomfort. This document won't have all possible interactions. https://www.proleviate.com/post/the-new-pain-killer-conolidine